Fourth Generation Biologics
A Fourth Generation Biologic is any man-made molecule that enters into the nucleus to accomplish a medically therapeutic task. Fourth Generation Biologics include synthetic transcription factors, transcription binding proteins, nuclear receptors, nuclear signaling proteins, DNA binding proteins, and control RNA molecules. Fourth Generation Biologics may target nuclear DNA, viral DNA, the transcription complex, the spliceosome, nucleolus, nucleosome, and RNA in the nucleus of a cell. The function of Fourth Generation Biologics include (a) to silence a viral genome by obstructing the viral gene’s unique identifier, or (b) activate/deactivate the body’s nuclear genes by utilizing a modified transcription factor to locate a gene’s unique identifier to turn ‘on’ or switch ‘off’ transcription of a specific gene, or (c) engage a specific spliceosome, nucleolus, nucleosome, or RNA in the nucleus of a cell. The immediate objective for developing Fourth Generation Biologics is to combat viral infections. The near term objective is to optimize management of diabetes mellitus by activating intracellular insulin production and/or intracellular insulin receptor production. The eventual goal is to develop Fourth Generation Biologics to develop medical therapies to cure osteoarthritis, fatal genetic disorders, and certain cancers.
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